|Systematic (IUPAC) name|
|ATC code||R01 R01 R03 S01 QG04|
|Half life||3–6 hours|
|Pregnancy cat.||A(AU) A(US)|
|Legal status||Prescription Only (S4) (AU) Schedule VI (CA) P (UK) OTC (US)|
|Routes||oral, IV, IM, SC|
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Ephedrine (EPH) [pronunciation: i-ˈfed-rən, British also ˈef-ə-drən] is a sympathomimetic amine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
Ephedrine is similar in structure to the (semi-synthetic) derivatives amphetamine and methamphetamine. Chemically, it is an alkaloid derived from various plants in the genus Ephedra (family Ephedraceae). It is most usually marketed in the hydrochloride and sulfate forms.
In traditional Chinese medicines, the herb má huáng (麻黄, Ephedra sinica) contains ephedrine and pseudoephedrine as its principal active constituents. The same is true of other herbal products containing extracts from Ephedra species.
Nagayoshi Nagai, a japanese chemist, was the first person to isolate ephedrine from Ephedra distachya (syn. Ephedra vulgaris) in 1885. The substance called soma mentioned in old Hindu books such as the Rig Veda, may have been ephedra extract. This, however, is disputed, as the identity of soma.
Ephedrine exhibits optical isomerism and has two chiral centres, giving rise to four diastereomers. By convention the enantiomers with opposite stereochemistry around the chiral centres (1R,2S and 1S,2R) are designated ephedrine, while pseudoephedrine has same stereochemistry around the chiral carbons (1R,2R and 1S,2S).
Ephedrine is a substituted amphetamine and a structural methamphetamine analogue. It differs from methamphetamine only by the presence of a hydroxyl (OH). Amphetamines, however, are more potent and have additional biological effects.
The isomer which is marketed is (-)-(1R,2S)-ephedrine.
Ephedrine hydrochloride has a melting point of 187-188°C.
The dextrorotary (+)- or d- enantiomer is (1S,2R)-Ephedrine, whereas the levorotating (−)- or l- form is (1R,2S)-Ephedrine.
Often the d/l system (with small caps) and the d/l system (with lower-case) are confused. The result is that the levorotary l-Ephedrine is wrongly named l-Ephedrine and the dextrorotary d-Pseudoephedrine (the diastereomer) wrongly d-Pseudoephedrine.
The IUPAC names of the two enantiomers are (1R,2S)- respectively (1S,2R)-2-methylamino-1-phenylpropan-1-ol. A synonym is erythro-Ephedrine.
Raw materials for the production of ephedrine and traditional Chinese medicine are produced in China on a large scale. In 2007, companies produced for export extract US$13 million worth of ephedrine from 30,000 tons of ephedra annually, 10 times the amount that is used in traditional Chinese medicine.
Ephedrine is a sympathomimetic amine. The principal mechanism of its action relies on its indirect stimulation of the adrenergic receptor system, which is part of the sympathetic nervous system (SNS), by increasing the activity of noradrenaline at the post-synaptic α- and β-receptors. The presence of direct interactions with α-receptors is unlikely, but still controversial.    Acting upon the central nervous system (CNS) is limited because ephedrine only crosses the blood-brain barrier weakly and not very efficiently.
The presence of an N-methyl group decreases binding affinities at α-receptors, compared with norephedrine. On the other hand ephedrine binds better than N-methylephedrine, which has an additional methyl group at the N-atom. Also the steric orientation of the hydroxyl group is important for receptor binding and functional activity.
In traditional Chinese medicine, ephedrine has been used in the treatment of asthma and bronchitis for centuries.
Both ephedrine and pseudoephedrine act as a bronchodilator, but pseudoephedrine has considerably less effect. Both also increase blood pressure, with again pseudoephedrine being considerably less effective. 
An ECA stack is a component found in thermogenic weight loss pills, composed of ephedrine, caffeine and aspirin (many supplement manufacturers include salicin instead of aspirin) working to speed up the metabolism and thus cause food energy to burn faster. The ECA stack is a popular supplement taken by body builders before workouts due to the increased amount of energy and alertness.
For many years, the US Coast Guard recommended ephedrine together with an equal 25 mg dose of promethazine to its sailors to combat seasickness. Promethazine manages nausea and ephedrine fights the ensuing drowsiness. Commonly referred to as the Coast Guard cocktail, ephedrine may still be available for prescription for this purpose.
Adverse drug reactions (ADRs) are more common with systemic administration (e.g. injection or oral administration) compared to topical administration (e.g. nasal instillations). ADRs associated with ephedrine therapy include:
The neurotoxicity of l-Ephedrine is disputed. 
Ephedrine should not be used in conjunction with certain antidepressants, namely SNRIs (serotonin-norepinephrine re-uptake inhibitors), as this increases the risk of the above symptoms due to excessive serum levels of norepinephrine.
Bupropion is an example of an antidepressant with an amphetamine-like structure similar to ephedrine, and it is known as an NDRI (norepinephrine-dopamine re-uptake inhibitor). It has an action which bears more resemblance to amphetamine than to fluoxetine in that its primary mode of therapeutic action involves norepinephrine and to a lesser degree dopamine, but it also releases some serotonin from presynaptic clefts. It should not be used with ephedrine as it may increase the likelihood of the above side effects.
Ephedrine should be used with caution in patients with inadequate fluid replacement, impaired adrenal function, hypoxia, hypercapnia, acidosis, hypertension, hyperthyroidism, prostatic hypertrophy, diabetes mellitus, cardiovascular disease, during delivery if maternal BP > 130/80 mmHg, and lactation.
Contraindications for the use of ephedrine include: closed angle glaucoma, phaeochromocytoma, asymmetric septal hypertrophy (idiopathic hypertrophic subaortic stenosis), concomitant or recent (previous 14 days) monoamine oxidase inhibitor (MAOI) therapy, general anaesthesia with halogenated hydrocarbons (particularly cyclopropane or halothane), tachyarrhythmias or ventricular fibrillation, hypersensitivity to ephedrine or other stimulants.
Ephedrine should not be used at any time during pregnancy unless specifically indicated by a qualified physician and only when other options are unavailable.
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Anecdotal reports have suggested that ephedrine helps studying, thinking, or concentrating to a greater extent than caffeine. Some students and some white-collar workers have used ephedrine (or Ephedra-containing herbal supplements) for this purpose, as well as some professional athletes and weightlifters. It is common for many athletes to use stimulants while exercising. Such use of ephedrine has been associated with stimulant dependence, as well as deaths from heatstroke in athletes and circulatory problems such as aortic aneurysm in weightlifters, though these side effects are rare.
As a phenylethylamine, ephedrine has a similar chemical structure to amphetamines and is a methamphetamine analogue having the methamphetamine structure with a hydroxyl group at the Rβ position. Because of ephedrine's structural similarity to methamphetamine it can be used to create methamphetamine using chemical reduction in which ephedrine's hydroxy group is removed; this has made ephedrine a highly sought-after chemical precursor in the illicit manufacture of methamphetamine. The most popular method for reducing ephedrine to methamphetamine is similar to the Birch reduction, in that it uses anhydrous ammonia and lithium metal in the reaction. The second most popular method uses red phosphorus, iodine, and ephedrine in the reaction.
In E for Ecstasy (a book examining the uses of the drug MDMA in the UK) the writer, activist and Ecstasy advocate Nicholas Saunders highlighted test results showing that certain consignments of the drug also contained ephedrine. Consignments of Ecstasy known as "Strawberry" contained what Saunders described as a "potentially dangerous combination of ketamine, ephedrine and selegiline," as did a consignment of "Sitting Duck" Ecstasy tablets.
Through oxidation, ephedrine can be easily synthesized into methcathinone. Ephedrine is listed as a Table I precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
Ephedrine is used in bulk quantities to produce chiral auxiliary groups.
Ephedrine distribution is controlled by the government, and pharmacists may refuse to sell it to customers without a prescription.
In 1997, the FDA proposed a regulation on ephedra (the herb from which ephedrine is obtained), which limited an ephedra dose to 8 mg (of active ephedrine) with no more than 24 mg per day. This proposed rule was withdrawn in part in 2000 because of "concerns regarding the agency's basis for proposing a certain dietary ingredient level and a duration of use limit for these products." In 2004, the FDA created a ban on ephedrine alkaloids that are marketed for reasons other than asthma, colds, allergies, other disease, or traditional Asian use. On April 14, 2005, the U.S. District Court for the District of Utah ruled that the FDA did not have proper evidence that low dosages of ephedrine alkaloids are actually unsafe, but on August 17, 2006, the U.S. Court of Appeals for the Tenth Circuit in Denver upheld the FDA's final rule declaring all dietary supplements containing ephedrine alkaloids adulterated, and therefore illegal for marketing in the United States. Ephedrine is, however, still legal in many applications outside of dietary supplements. However, purchasing is currently limited and monitored, with specifics varying from state to state.
The House passed the Combat Methamphetamine Epidemic Act of 2005 as an amendment to the renewal of the USA PATRIOT Act. Signed into law by president George W. Bush on March 6, 2006, the act amended the US Code (21 USC 830) concerning the sale of ephedrine-containing products. The federal statute included the following requirements for merchants who sell these products:
The law gives similar regulations to mail-order purchases, except the monthly sales limit is only 7.5 grams.
In the UK ephedrine is regulated as a P medicine: it may only be lawfully supplied within a registered pharmacy and while a responsible pharmacist is present. The maximum amount of ephedrine legally available without prescription in one sale is 180mg- the only product commonly sold within these restrictions is ChestEze tablets which consist of 9 pills of 18.75mg ephedrine combined with caffeine and theophylline. These are intended as a nasal decongestant but are known to be used by bodybuilders. Higher strengths of pure ephedrine are available as prescription-only medicines but are not currently Controlled Drugs under the Misuse of Drugs Act.
In South Africa ephedrine was rescheduled to Schedule 6 on 27 May 2008 , which, as in the UK, is legal to possess but available via a prescription only.
The content of this section is licensed under the GNU Free Documentation License (local copy). It uses material from the Wikipedia article "Ephedrine" modified November 23, 2009 with previous authors listed in its history.